Sceletium tortuosum Sceletium tortuosum (also known as Kanna) is a succulent plant commonly found in South Africa. Many of its psychoactive effects are similar to but less intense than the effects of empathogens such as MDMA. … Kanna is sometimes used as an anti-depressant as a replacement for pharmaceutical anti-depressants. It has a long history of use as a traditional medicine by tribes of South Africa. It has been used to enhance mood, cause relaxation, and euphoria. Traditionally, the roots and leaves were fermented and then chewed. It has also been used as snuff, smoked, or made into a tea or tincture. Sceletium is 100% safe and non addictive.